On a city trip in Europe? Chances are you will catch the plane. In 1995, Schiphol had nearly 240,000 European flight movements each year, and more than 400,000 last year. Flights to and from Barcelona even climbed from 2507 to 8476 per year during that period.
Alternatives became scarcer in that period: many international night trains were canceled. Around 30 lines have been deleted since 1995, including those between Amsterdam and Berlin. If you add that flying has suffered damage to its image due to environmental impact, then that could have consequences for your ideal weekend away.
On the page below you can indicate how long you want to be on the road, how much money you want to spend and whether you want to fly or not. Based on the choices you make, certain cities fall out that do not meet your criteria.
See here if you get further than Berlin: